Mixed Lymphocyte Culture vs Autoimmune Polyendocrine/Polyglandular Syndrome

These compounds stimulate the membranes of neurons of the CNS benzodiazepine receptors, which are allosterically linked to GAMKAretseptorami. Characterized by a pronounced withdrawal syndrome: anxiety, insomnia, nightmares, confusion, tremor. Thus, benzodiazepines reinforce the processes of inhibition in the CNS. On certain days of treatment patients receive small amounts of alcohol (40-50 market magnitudes of vodka). Patients strongly warns against, the market magnitudes of drinking alcohol during the period of preparation. From blockers H1retseptorov just as hypnotic use doxylamine (donormil) - preparation, virtually no influences the sleep pattern. Prolonged dosage form of disulfiram implantation in the form of tablets sold under the name «esperal. The drug reduces the excessive reaction to outside stimuli, contributes to onset of sleep and provides sleep for 6-8 hours when the systematic application of nitrazepama may show its side effects: lethargy, sleepiness, decreased alertness, slowed reactions, possible diplopia, nystagmus, itching, rash. The resulting acetaldehyde is «nuyu Antabuse reaction» - facial flushing, throbbing here hypotension, dizziness, palpitations, shortness of breath, muscle tremors, anxiety, sweating, thirst, nausea, vomiting. Therefore, treatment of disulfiram can be conducted only under strict medical supervision. In specialized hospital alcoholic Nerve Conduction Study regularly prescribed disulfiram tablets. As a result, only one type of or the smell of alcohol causes in patients nausea and vomiting. It should be borne in mind that during treatment with disulfiram alcohol intoxication at the reception can take place very heavy and accompanied by vascular collapse, respiratory depression, loss of consciousness, seizures. Distinguish between hypnotics with non-narcotic type of action (benzodiazepines and others), hypnotics with narcotic type of action (barbiturates, chloral hydrate). Melatonin - a synthetic analogue of the hormone of pineal gland involved in the provision market magnitudes circadian rhythms change of wakefulness and sleep. Tablets sewn into the subcutaneous tissue, and their gradual resorption provides long-term circulation of disulfiram in blood. Pronounced hypnotic effect market magnitudes for example, diphenhydramine (diphenhydramine), which, however, often used as anti-allergic agent. Nebenzodiazepinovye stimulants benzodiazepine receptor zolpidem (ivadal) and zopiclone (imovan) have little effect on sleep structure, do not have pronounced muscle relaxant and anticonvulsant action, not cause withdrawal symptoms and market magnitudes better tolerability profile. The mechanism of hypnotic action is associated with potentiation inhibitory action of GABA. Barbiturates increase the sensitivity of GAMKAretseptorov and thus activate C1 channels and cause hyperpolarization of the membrane of neurons. Barbiturates - High-hypnotics, and help sleep onset, warn frequent waking, increase total sleep time. Typically, acetaldehyde is rapidly oxidized ацетальдегиддегидрогеназой. However, this several changes of sleep structure: it decreases the duration REMfaz sleep (REM sleep, REM sleep: periods of 20-25 mines, which are repeated during sleep several times, accompanied by dreams and Everyday movements of the eyeballs - Rapid Eye Movements).